Oestrogen-induced DNA damage drives genomic instability in BRCA1 mutation cells, with dietary compounds showing protective potential.

Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.

Patients with this genetic disorder have a form of dwarfism — they are short in stature and have underdeveloped ears and ...

New research has found that oestrogen-induced DNA damage in individuals carrying BRCA1 mutations may play a crucial role in the initiation of cancer, while also pointing to a potential dietary ...

DNA polymerase epsilon catalytic subunit A (POLE) gene plays a crucial role in DNA repair and chromosomal replication. Mutations in the POLE gene have been linked to cancer, particularly colorectal ...

UC San Diego professor Ludmil Alexandrov will lead an international team of scientists awarded $25 million to research cancer mutations. The award comes from Cancer Grand Challenges, a collaboration ...