Membrane protein targeting and insertion is a fundamental process in cellular biology that ensures proteins are correctly delivered to, and integrated within, the lipid bilayer. Proteins destined for ...

A protein already targeted by FDA-approved cancer drugs may also help the body fight influenza, according to new research ...

Findings from preclinical studies could point to therapeutic strategies for Huntington’s disease, as well as other neurodegenerative disorders and potentially cancer.

Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded ...

Researchers have created nanoparticles that can remove disease-driving proteins while also delivering a chemotherapeutic or ...

A multinational research team led by researchers at Institute of Science Tokyo, RIKEN, and the University of Toronto has ...

Cells face constant threats from inside and out. Thus, they’ve evolved sophisticated stress response pathways such as the unfolded protein response (UPR), ...

Intrinsically disordered proteins lack a fixed structure, which is why they have been considered "undruggable" targets for drug development for years. However, these proteins play a key role in ...

Acurastem received a grant to develop ALS therapies targeting SYF2, a regulator of TDP-43, in collaboration with academic ...

Northwestern Medicine scientists have zeroed in on a cellular gatekeeper that may hold promise for treating abnormal protein accumulation in neurodegenerative diseases, according to a study published ...

Scientists have discovered a previously unknown pathway that allows toxic proteins linked to Huntington’s disease to spread ...