For the first time, the structure of a DNA enzyme complex implicated in infertility and cancer has been obtained using cryo-electron microscopy (cryo-EM). A collaboration of researchers, led by ...

Scientists have prototyped a new method for 'rationally engineering' enzymes to deliver improved performance. They have devised an algorithm, which takes into account an enzyme's evolutionary history, ...

While most enzymatic activity is conducted through chemical binding interactions between molecules, in some cases, the mere presence of an enzyme can affect intracellular functions. While exploring ...

When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system. Enzymes usually clear these nucleic acids before they cause an issue, but when these ...

Specific glycans attached to the GnT-IVa and GnT-IVb can bind to the enzyme’s ligand-binding site, interfering with recognition and binding to the glycosylation proteins’ normal glycoprotein ...

Researchers from the University of Seville have participated in research to identify the molecular details of the regulation of an enzyme essential for sugar metabolism and closely linked to cell ...

Nitrilases are a unique class of enzymes that catalyse the hydrolysis of nitrile compounds to yield the corresponding carboxylic acids or amides. Their application in biotransformation processes has ...

The snapshots reveal key reactions steps. At 0 ms, water molecules occupy the substrate-binding site. At 50 ms, a substrate-cofactor intermediate forms. At 100 ms, the product is released, and the ...

Researchers have found that peroxiredoxins, a family of antioxidant enzymes central to how cells manage oxidative stress, can ...